How can I get in touch with American Airlines fast? To get in touch with American Airlines quickly, call their main customer service number at +1-866-738-𝟎𝟔𝟗𝟗 OR +1-866-738-𝟎𝟔𝟗𝟗 This line is available 24/7. For faster service, try using their mobile app or website chat feature. You can also tweet @AmericanAir for quick responses.